Phenotypes Associated with This Genotype

Genotype
MGI:3766076

• Allelic Composition: Tg(Ela1-TAg)18Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:76995 )

• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors

• 3 islet cell carcinomas develop

increased pancreatic islet cell adenoma incidence ( J:76995 )

• 77% of mice form benign or low-grade islet cell tumors

• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin

increased insulinoma incidence ( J:76995 )

• most islet cell tumors are composed of beta cells

increased pancreatic acinar cell carcinoma incidence ( J:76995 )

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:76995 )

pancreatic islet hyperplasia ( J:76995 )

increased pancreas tumor incidence ( J:76995 )

• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors

• 3 islet cell carcinomas develop

increased pancreatic islet cell adenoma incidence ( J:76995 )

• 77% of mice form benign or low-grade islet cell tumors

• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin

increased insulinoma incidence ( J:76995 )

• most islet cell tumors are composed of beta cells

increased pancreatic acinar cell carcinoma incidence ( J:76995 )

pancreas inflammation ( J:107545 )

• infiltrate localized to perivascular region is detected

immune system

pancreas inflammation ( J:107545 )

• infiltrate localized to perivascular region is detected

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:76995 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:76995