Phenotypes Associated with This Genotype

Genotype
MGI:3761174

• Allelic Composition: Tg(MMTV-neu/OT-I/OT-II)CBnel/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:122846 )

• only ~50% of females develop mammary tumors by 16 months of age

increased lung tumor incidence ( J:122846 )

• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:122846 )

• only ~50% of females develop mammary tumors by 16 months of age

integument

increased mammary gland tumor incidence ( J:122846 )

• only ~50% of females develop mammary tumors by 16 months of age

respiratory system

increased lung tumor incidence ( J:122846 )

• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:122846