Phenotypes Associated with This Genotype

Genotype
MGI:3758451

cx3

• Allelic Composition: Igkc^tm1(IGKC)Mnz/Igkc⁺; Rr158^tm1(Igh)Xu/Rr158⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:124407 )

• the efficiency of rearrangement of the Igk-Eik^tm1(Igh)Xu allele is lower than that of the wild-type allele

decreased B cell number ( J:124407 )

• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eik^tm1(Igh)Xu

hematopoietic system

decreased B cell number ( J:124407 )

• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eik^tm1(Igh)Xu