Phenotypes Associated with This Genotype

Genotype
MGI:3721897

cx13

• Allelic Composition: Hoxa13^tm1Ipc/Hoxa13^tm1Ipc; Hoxd13^tm1Ddu/Hoxd13⁺
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:36214 )

• mice are not recovered after E14.5

limbs/digits/tail

abnormal carpal bone morphology ( J:36214 )

• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation

abnormal digit morphology ( J:36214 )

• digits lack separation and segmentation and tend to fuse terminally

• mice lack digit I and some mice have a minute posterior extra digit cartilage

abnormal tarsal bone morphology ( J:36214 )

• the tarsus is altered more than in Hoxa13^tm1Ipc/ Hoxa13⁺ Hoxd13^tm1Ddu/Hoxd13^tm1Ddu mice

• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows

abnormal digit development ( J:36214 )

• in the hindlimbs condensations for digits I through V are apparent but are irregular and remain in a primitive state

• in the hindlimbs, there is no chondrification in digit rays II and V

abnormal embryonic autopod plate morphology ( J:36214 )

• foot plates are narrower, especially towards the distal extremities, when compared with Hoxa13^tm1Ipc/ Hoxa13⁺ Hoxd13^tm1Ddu/Hoxd13^tm1Ddu mice

skeleton

abnormal carpal bone morphology ( J:36214 )

• with the exception of an altered pisiform cartilage, there is no individualization of carpal condensation

abnormal tarsal bone morphology ( J:36214 )

• the tarsus is altered more than in Hoxa13^tm1Ipc/ Hoxa13⁺ Hoxd13^tm1Ddu/Hoxd13^tm1Ddu mice

• none of the tarsus blastemas are properly individualized and there is no separation between proximal and distal rows