Phenotypes Associated with This Genotype

Genotype
MGI:3720910

• Allelic Composition: Basp1^tm1Crni/Basp1^tm1Crni
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Neuromuscular junction abnormalities in Basp1^tm1Crni/Basp1^tm1Crni mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:63023 )

• only 10% of mice survive to adulthood

nervous system

abnormal Schwann cell morphology ( J:63023 )

• from P12 to P15, terminal Schwann cells in the neuromuscular junction exhibit abnormalities such as being loosely packed, hypertrophic and having excessive growth into the extracellular space

• some nerve terminals are completely wrapped in Schwann cells

enlarged brain ventricles ( J:63023 )

• adult mice have enlarged ventricles

abnormal hippocampus morphology ( J:63023 )

• adult mice have abnormal axonal and synaptic ultrastructures

abnormal cerebral cortex morphology ( J:63023 )

• adult mice have abnormal axonal and synaptic ultrastructures

abnormal neuron morphology ( J:63023 )

• from P12 to P15, nerve terminals in the neuromuscular junction exhibit abnormalities such as irregular shapes, swellings and blocklike endings

• some nerve terminals are completely wrapped in Schwann cells

abnormal axon extension ( J:63023 )

• neurites extend axons that are thin and twisty with varicosities and bulbous endings compared to axons in wild-type mice and can be phenocopied by the exposure of wild-type neurites to cytochalasin

abnormal neurite morphology ( J:63023 )

• neurites extend axons that are thin and twisty with varicosities and bulbous endings compared to axons in wild-type mice and can be phenocopied by the exposure of wild-type neurites to cytochalasin

abnormal axon morphology ( J:63023 )

• adult mice have abnormal axonal ultrastructure in the hippocampus and neocortex

abnormal neuromuscular synapse morphology ( J:63023 )

• from P12 to P15, nerve terminal and terminal Schwann cells exhibit abnormalities

• 90% of neuromuscular junctions exhibit abnormalities

abnormal motor nerve collateral sprouting ( J:63023 )

• after induction of sprouting with botulinum toxin A, little to no nerve sprouting occurs in the soleus muscle unlike in wild-type mice

growth/size/body

decreased body weight ( J:63023 )

• adult mice weigh 50 to 70% of their wild-type littermates

behavior/neurological

hyperactivity ( J:63023 )

• adult mice are hyperactive

cellular

abnormal Schwann cell morphology ( J:63023 )

• from P12 to P15, terminal Schwann cells in the neuromuscular junction exhibit abnormalities such as being loosely packed, hypertrophic and having excessive growth into the extracellular space

• some nerve terminals are completely wrapped in Schwann cells

abnormal axon extension ( J:63023 )

• neurites extend axons that are thin and twisty with varicosities and bulbous endings compared to axons in wild-type mice and can be phenocopied by the exposure of wild-type neurites to cytochalasin