Phenotypes Associated with This Genotype

Genotype
MGI:3720804

• Allelic Composition: Tg(Ckm-APPSw)A6Lfa/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:76338 )

• beginning at 15-20 months of age, mice show significantly diminished performance on the accelerating rotarod relative to nontransgenic controls; diminished ability is observed at 10-15 months of age, but does not reach significance

nervous system

amyloid beta deposits ( J:76338 )

• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age

muscle

myositis ( J:76338 )

• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle

• neutrophils are the predominant infiltrating cell type

centrally nucleated skeletal muscle fibers ( J:76338 )

• between 15-20 and 20-30 months of age, muscle fibers with centric nuclei are seen in transgenic mice

immune system

myositis ( J:76338 )

• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle

• neutrophils are the predominant infiltrating cell type

homeostasis/metabolism

amyloid beta deposits ( J:76338 )

• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inclusion body myositis		DOID:3429	OMIM:147421	J:76338