Phenotypes Associated with This Genotype

Genotype
MGI:3720731

• Allelic Composition: Tg(Thy1-APP)3Somm/0
• Genetic Background: B6.Cg-Tg(Thy1-APP)3Somm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:80919 )

• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation

cerebral amyloid angiopathy ( J:80919 )

• vascular amyloid is associated with ectopic entorhinal boutons

abnormal axon morphology ( J:80919 )

• axons that line the periphery of beta-amyloid plaques exhibit swelling unlike in wild-type mice

• entorhinal fibers extend outside the termination zone unlike in wild-type mice

• commissure axons extend into the outer molecular layer unlike in wild-type mice

• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation

• vascular amyloid is associated with ectopic entorhinal boutons

behavior/neurological

increased exploration in new environment ( J:101283 )

• at 6 months during the first 2 hours

abnormal spatial learning ( J:80449 )

• impaired acquisition in the Morris water maze; the number of quadrant entries and the escape latencies are higher than in controls

• however, mutants are unaffected in open-field, elevated plus-maze, emergence tests, tests measuring motor coordination, during the probe trial and while swimming towards a visible platform

increased aggression towards mice ( J:152518 )

• in an isolation-induced/resident-intruder paradigm, mice exhibit a 4.6- and 59-fold increase in aggression at 6 and 12 months, respectively, compared with wild-type mice

jumpy ( J:80449 )

• 67% of animals exhibit myoclonic jumping behavior in home cage

abnormal locomotor activation ( J:80449 )

• reduced number of horizontal and vertical movements in the photocell monitor

abnormal locomotor circadian rhythm ( J:101283 )

• at 3 months, mice exhibit lower light ambulation compared with wild-type mice

• at 6 months, mice exhibit increased in the ratio of dark to light ambulation during the second half of the active phase compared with wild-type mice

• at 12 months, circadian locomotor patterns are more constant than in wild-type mice

• at 12 months, mice exhibit increased dark and total ambulation compared with wild-type mice

• at 12 months, dark ambulation level is bimodal unlike in wild-type mice

hyperactivity ( J:101283 )

• overnight at 12 months

growth/size/body

decreased body weight ( J:80449 )

• 29% weight reduction compared to wild-type

homeostasis/metabolism

amyloid beta deposits ( J:80919 )

• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation

cerebral amyloid angiopathy ( J:80919 )

• vascular amyloid is associated with ectopic entorhinal boutons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:80449