Phenotypes Associated with This Genotype

Genotype
MGI:3719205

ot1

• Allelic Composition: Krt71^Ca-Rin/?
• Genetic Background: C57BL/6Slc-Krt71^Ca-Rin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:86407 )

• at 5 weeks, dorsal skin in thinner than in wild-type mice mainely due to a thin adipose layer

endocrine/exocrine glands

enlarged sebaceous gland ( J:86407 )

integument

decreased subcutaneous adipose tissue amount ( J:86407 )

• at 5 weeks, dorsal skin in thinner than in wild-type mice mainely due to a thin adipose layer

enlarged sebaceous gland ( J:86407 )

rough coat ( J:86407 )

greasy coat ( J:86407 )

waved hair ( J:86407 )

• hair is wavy and points in all directions

• after 4 weeks, the wavy hair is less apparant but mice maintain a plush-like appearance

abnormal hair follicle morphology ( J:86407 )

• follicles are curved and twisted randomly to different extents

• follicular-derived cysts containing keratin debris form

abnormal hair follicle inner root sheath morphology ( J:86407 )

• the inner root sheath lacks uniform thickness and in some follicles shows abnormal keratinization

thin skin ( J:86407 )

• at 5 weeks, dorsal skin in thinner than in wild-type mice mainely do to a thin adipose layer