Phenotypes Associated with This Genotype

Genotype
MGI:3718515

• Allelic Composition: Tg(APP)8.9Btla/Tg(APP)8.9Btla
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired short-term object recognition memory ( J:96742 )

• at 5.5 months of age, mice do not appear to recall platform position from the previous day of training and show a lower learning rate over subsequent trials

• impairment observed at 10 months of age

increased exploration in new environment ( J:96742 )

• exploratory behavior is increased for both familiar and novel objects

abnormal spatial learning ( J:96742 )

• at 9 months, a delay of learning process in Morris water maze is observed compared to controls

decreased anxiety-related response ( J:96742 )

• mice spend less time per entry into dark arms than controlsmice spend less time per entry into dark arms than controls

• mice exit dark side of dark-light box more often than controls

abnormal locomotor activation ( J:96742 )

• transgenic mice display more spontaneous locomotor activity than controls; activity is higher than in Tg(APP)8.9Btla or Tg(SOD1)51Yg mice

vision/eye

vision/eye phenotype ( J:80534 )

N • little or no perturbation of the retinas structure or cornea is observed

abnormal lens morphology ( J:80534 )

• numerous bodies with circular profiles are present in all lens sections examined

• circles are present in lenses from mice >6 months of age; circles are 1-5 um in diameter

• lenses from 6 and 16 month-old mice contain swollen cortical fiber cells and lens plaques

• fiber cell nuclei are disorganized in the outer cortical region compared to wild-type

• lens degeneration is variable in severity and onset; in some cases, one lens is more severely affected than the other side

abnormal lens fiber morphology ( J:80534 )

• individual fiber cells are irregularly shaped and fiber cell arrays are misaligned

• lens fiber cell membranes are morphologically abnormal

• mice display age-related fiber cell degeneration and cortical plaque formation

nervous system

nervous system phenotype ( J:96742 )

N • no Abeta peptides are detected in 5 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:96742