Phenotypes Associated with This Genotype

Genotype
MGI:3718115

• Allelic Composition: Tg(Camk2a-MAPT*R406W)748Atak/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:100958 )

• mortality of transgenic mice is higher than in non-transgenic littermates

behavior/neurological

abnormal contextual conditioning behavior ( J:100958 )

• in contextual testing 24 hours after conditioning, mutants and control mice show similar levels of freezing; however, in testing conducted 15 days after conditioning, transgenic mice show significantly lower levels of freezing than control littermates suggesting impaired establishment of permanent memory

abnormal cued conditioning behavior ( J:100958 )

• transgenic mice show reduced levels of fear response in a cued conditioning paradigm, as shown by lower levels of freezing after foot shocks

nervous system

tau protein deposits ( J:100958 )

• congophilic tau inclusions are seen in a subset of forebrain neurons in aged mice (18 months); these inclusions are analogous to neurofibrillary tangles seen in humans

decreased prepulse inhibition ( J:100958 )

• a significant decrease in prepulse inhibition of the startle response in aged mice relative to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
frontotemporal dementia		DOID:9255	OMIM:600274	J:100958