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Phenotypes Associated with This Genotype
Genotype
MGI:3717262
Allelic
Composition		 Arctm1.1Kuhl/Arctm1.1Kuhl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arctm1.1Kuhl mutation (0 available); any Arc mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal AMPA-mediated synaptic currents ( J:122964 )
• AMPA receptor function is increased
• AMPA receptor scaling is absent following TTX and bicuculine treatments
abnormal miniature excitatory postsynaptic currents ( J:122964 )
• following TTX treament, mice fail to produce an enhanced miniature excitatory postsynaptic current as wild-type mice do

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory