Phenotypes Associated with This Genotype

Genotype
MGI:3717127

cx14

• Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺; Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Schip1^{Gt(ROSA)77Sor} homozygotes

renal/urinary system

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often swollen and degraded

• smooth muscle cell number is reduced in the glomeruli

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli