Phenotypes Associated with This Genotype

Genotype
MGI:3715978

• Allelic Composition: Dvl1^tm1Awb/Dvl1^tm1Awb; Dvl2^tm1Awb/Dvl2^tm1Awb
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enlarged floor plate ( J:108512 )

• the floor plate is expanded

open neural tube ( J:108512 )

• neural tube fails to close in 100% of embryos

abnormal orientation of outer hair cell stereociliary bundles ( J:108512 )

• the stereociliary bundle orientation in the cochlea is disrupted at 100% penetrance

abnormal cochlear inner hair cell morphology ( J:108512 )

• occasionally misaligned inner hair cells are obverse

hearing/vestibular/ear

abnormal orientation of outer hair cell stereociliary bundles ( J:108512 )

• the stereociliary bundle orientation in the cochlea is disrupted at 100% penetrance

abnormal cochlear inner hair cell morphology ( J:108512 )

• occasionally misaligned inner hair cells are obverse

embryo

abnormal embryo development ( J:108512 )

• at the 5- through 8- somite stage, the embryo length to width ratio is reduced

• there is no increase in embryo length to width ratio from 5 to 7 somite stage

enlarged floor plate ( J:108512 )

• the floor plate is expanded

open neural tube ( J:108512 )

• neural tube fails to close in 100% of embryos

abnormal notochord morphology ( J:108512 )

• the notochord is wider