Phenotypes Associated with This Genotype

Genotype
MGI:3714979

• Allelic Composition: Cyld^tm1Ref/Cyld^tm1Ref
• Genetic Background: B6.129-Cyld^tm1Ref

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:108769 )

• treatment of mice in 7,12-dimethylbenz(a)antracene (DMBA) followed by 12-O-tetradecanoylphorbol-13 acetate (TPA) results in tumor formation with 7-11 week latency in all mutants whereas only 50% of wild-type mice develop papillomas after 11-16 weeks

• induced homozygotes develop 7-fold more, significantly larger papillomas than control littermates

• tumors in mutants and controls have a hyperplastic squamous epithelium with no sign of malignancy

cellular

abnormal keratinocyte proliferation ( J:108769 )

• exposure of keratinocytes to small interfering RNA specific for Bcl-3 abrogates TPA-induced proliferation

increased cell proliferation ( J:108769 )

• tumors exhibit large numbers of proliferating cells above the basal layer, which is not seen in tumors from wild-type mice; however apoptosis in tumors is similar to tumors in wild-type mice

increased keratinocyte proliferation ( J:108769 )

• TPA treatment induces proliferation in isolated Cyld-null keratinocytes

integument

abnormal keratinocyte proliferation ( J:108769 )

• exposure of keratinocytes to small interfering RNA specific for Bcl-3 abrogates TPA-induced proliferation

increased keratinocyte proliferation ( J:108769 )

• TPA treatment induces proliferation in isolated Cyld-null keratinocytes

epidermal hyperplasia ( J:108769 )

• a single dose of TPA induces epidermal hyperplasia and increases keratinocyte proliferation in back skin of mutants, but even after 20 weeks of treatment no tumor formation is observed

increased skin papilloma incidence ( J:108769 )

• treatment of mice in 7,12-dimethylbenz(a)antracene (DMBA) followed by 12-O-tetradecanoylphorbol-13 acetate (TPA) results in tumor formation with 7-11 week latency in all mutants whereas only 50% of wild-type mice develop papillomas after 11-16 weeks

• induced homozygotes develop 7-fold more, significantly larger papillomas than control littermates

• tumors in mutants and controls have a hyperplastic squamous epithelium with no sign of malignancy