Phenotypes Associated with This Genotype

Genotype
MGI:3714352

• Allelic Composition: Cd80^tm1Shr/Cd80^tm1Shr; Cd86^tm2Shr/Cd86^tm2Shr; Ctla4^tm1Shr/Ctla4^tm1Shr
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell physiology ( J:57090 )

• T cells differentiate into Th2 cells upon anti-CD3 stimulus

increased T cell proliferation ( J:57090 )

• during secondary stimulation with anti-CD3 and antigen-presenting cells, CD4+ T cells proliferate more than Ctla4-sufficient, CD80/86 null cells

abnormal cytokine secretion ( J:57090 )

• cells produce Il-4 even during primary stimulation with anti-CD3 and APCs, whereas Ctla4-sufficient mice do not, and on secondary stimulation, cells produce more Il-4 and less interferon gamma than Ctla4-sufficient cells

• upon anti-CD28 stimulation in vivo, cells produce Il-4 but wild-type cells do not; mice show less interferon gamma production after anti-CD28 treatment than wild-type mice

hematopoietic system

abnormal T cell physiology ( J:57090 )

• T cells differentiate into Th2 cells upon anti-CD3 stimulus

increased T cell proliferation ( J:57090 )

• during secondary stimulation with anti-CD3 and antigen-presenting cells, CD4+ T cells proliferate more than Ctla4-sufficient, CD80/86 null cells

cellular

increased T cell proliferation ( J:57090 )

• during secondary stimulation with anti-CD3 and antigen-presenting cells, CD4+ T cells proliferate more than Ctla4-sufficient, CD80/86 null cells