Phenotypes Associated with This Genotype

Genotype
MGI:3710355

• Allelic Composition: Brca1^tm1Aash/Brca1^tm1Aash; Tg(LGB-cre)74Acl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased salivary adenocarcinoma incidence ( J:119996 )

• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

increased mammary gland tumor incidence ( J:119996 )

• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

integument

increased mammary gland tumor incidence ( J:119996 )

• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

endocrine/exocrine glands

increased salivary adenocarcinoma incidence ( J:119996 )

• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

increased mammary gland tumor incidence ( J:119996 )

• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

digestive/alimentary system

increased salivary adenocarcinoma incidence ( J:119996 )

• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

growth/size/body

increased salivary adenocarcinoma incidence ( J:119996 )

• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

craniofacial

increased salivary adenocarcinoma incidence ( J:119996 )

• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:119996