Phenotypes Associated with This Genotype

Genotype
MGI:3697617

• Allelic Composition: Hrc^tm1Blk/Hrc^tm1Blk
• Genetic Background: B6.129S6-Hrc^tm1Blk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:117648 )

• exhibit impaired weight gain beginning at 11 months of age

weight loss ( J:117648 )

• exhibit weight loss beginning at 11 months of age

cardiovascular system

cardiovascular system phenotype ( J:117648 )

N • hearts exhibit normal calcium handling

increased response of heart to induced stress ( J:117648 )

• display increased susceptibility to isoproterenol-induced cardiac hypertrophy

adipose tissue

abnormal fat pad morphology ( J:117648 )

• impaired weight gain is marked by reduced fat pad mass

muscle

decreased skeletal muscle mass ( J:117648 )

• impaired weight gain is marked by reduced skeletal muscle mass

behavior/neurological

behavior/neurological phenotype ( J:117648 )

N • exhibit no difference in voluntary exercise performance compared to wild-type

homeostasis/metabolism

increased response of heart to induced stress ( J:117648 )

• display increased susceptibility to isoproterenol-induced cardiac hypertrophy