Phenotypes Associated with This Genotype

Genotype
MGI:3690452

• Allelic Composition: Dnd1^Ter/Dnd1^Ter
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased testicular teratoma incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic mutants

♂ • 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas

reproductive system

increased testicular teratoma incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic mutants

♂ • 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas

endocrine/exocrine glands

increased testicular teratoma incidence ( J:7954 )

♂ • Background Sensitivity: incidence is reduced after backcrossing for several generations compared to coisogenic mutants

♂ • 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas