Phenotypes Associated with This Genotype

Genotype
MGI:3664440

• Allelic Composition: Blm^tm1Ches/Blm^tm4Ches; Tg(LGB-cre)74Acl/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:112115 )

• in mice aged 13-19 months, mammary tumors, mainly adenocarcinomas, developed in 7/25 females compared to 1/20 non-conditional knockout mice

• no tumor cell lines could be produced from tumors for analyses of chromosomal instability in these mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:112115 )

• in mice aged 13-19 months, mammary tumors, mainly adenocarcinomas, developed in 7/25 females compared to 1/20 non-conditional knockout mice

• no tumor cell lines could be produced from tumors for analyses of chromosomal instability in these mice

integument

increased mammary adenocarcinoma incidence ( J:112115 )

• in mice aged 13-19 months, mammary tumors, mainly adenocarcinomas, developed in 7/25 females compared to 1/20 non-conditional knockout mice

• no tumor cell lines could be produced from tumors for analyses of chromosomal instability in these mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bloom syndrome		DOID:2717	OMIM:210900	J:112115