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Phenotypes Associated with This Genotype
Genotype
MGI:3664020
cn1
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased response of heart to induced stress ( J:109612 )
• mutants treated with tamoxifen and subjected to thoracic aortic constriction exhibit a reduced hypertrophic response to the pressure overload

homeostasis/metabolism
decreased response of heart to induced stress ( J:109612 )
• mutants treated with tamoxifen and subjected to thoracic aortic constriction exhibit a reduced hypertrophic response to the pressure overload

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory