Phenotypes Associated with This Genotype

Genotype
MGI:3662919

• Allelic Composition: Foxd3^tm1Lby/Foxd3^tm1Lby
• Genetic Background: involves: 129S6/SvEvTac * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta labyrinth morphology ( J:101652 )

• labyrinthine precursors are absent

abnormal trophoblast layer morphology ( J:101652 )

• giant cells are produced but the spongiotrophoblast lineage is absent

• marker analysis indicates that the fate of trophoblast precursor cells is shifted towards production of giant cells and away from development of spongiotrophoblast and labyrinthine lineages

• undifferentiated trophoectodermal cells are present at E8.0 but absent by E9.0 indicating a failure to maintain the multipotent progenitor cell population

• unable to derive trophoblast stem cell lines from E3.5 embryos or E6.5 extraembryonic ectoderm

absent spongiotrophoblast layer ( J:101652 )

• the spongiotrophoblast lineage is absent