About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3654648
Allelic
Composition
Ubr1tm1Avar/Ubr1tm1Avar
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr1tm1Avar mutation (0 available); any Ubr1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• chymotrypsin and elastase activities are lower in feces, indicating impaired pancreatic exocrine function, however observe no morphological differences in the pancreas
• pancreatic acini are about 100 times less responsive to secretagogue (cholecytoskinin) stimulation, indicating impaired stimulus-secretion coupling in the pancreas

endocrine/exocrine glands
• exhibit increased susceptibility to pancreatic injury (induced by cerulein to block secretion and induce acinar cell stress and experimental pancreatitis)
• chymotrypsin and elastase activities are lower in feces, indicating impaired pancreatic exocrine function, however observe no morphological differences in the pancreas
• pancreatic acini are about 100 times less responsive to secretagogue (cholecytoskinin) stimulation, indicating impaired stimulus-secretion coupling in the pancreas

behavior/neurological
• enhanced non spatial learning
• exhibit superior relearning, though equal first-day retention, on the Lashely III maze
• perform better in passive avoidance with 92% of mice not re-entering the dark compartment as opposed to 50% of wild-type, but only on the first day of testing, as show similar behavior to wild-type on day 2
• acquire horizontal-vertical discrimination more quickly
• take longer and swim a greater distance to locate the hidden platform during an 8-week Morris water maze retention, indicating impaired spatial learning
• exhibit less spontaneous activity in an open filed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Johanson-Blizzard syndrome DOID:14694 OMIM:243800
J:105229


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
03/14/2023
MGI 6.22
The Jackson Laboratory