Phenotypes Associated with This Genotype

Genotype
MGI:3652920

• Allelic Composition: Nhlh2^tm1Irk/Nhlh2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to age related obesity ( J:96351 )

• male heterozygotes weigh significantly more than wild-type males at 12-25 weeks of age, with the exception of week 19; by 52 weeks, male heterozygotes are significantly heavier than wild-type males (average 46.52 g vs 39.07 g, respectively) with significantly more body fat

• unlike males, female heterozygotes show normal body weights at 11 and 25 weeks of age, and are not significantly heavier than wild-type females at 52 weeks

adipose tissue

increased percent body fat/body weight ( J:96351 )

• at >52 weeks, male (but not female) heterozygotes show a significantly increased percent body fat relative to wild-type littermates, indicating a sex difference

behavior/neurological

polyphagia ( J:96351 )

• at 12-19 weeks of age, male (but not female) heterozygotes exhibit significantly increased food intake over wild-type males

abnormal motor capabilities/coordination/movement ( J:96351 )

• unlike male heterozygotes, female heterozygotes are comparable to female homozygotes with respect to daily voluntary activity, showing a significant reduction of daily wheel rotations/stage relative to wild-type females