Phenotypes Associated with This Genotype

Genotype
MGI:3629079

• Allelic Composition: Nptx1^tm1Mspn/Nptx1^tm1Mspn; Nptx2^tm1Mspn/Nptx2^tm1Mspn
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation ( J:109215 )

• at P10 retinal ganglion cell projections into the dorsal lateral geniculate nucleus (dLGN) lack eye specific segregation with projections from the contralateral filling the entire dLGN overlapping with single or multiple ipsalateral eye projection zones

• at P30 retinal ganglion cell projections appear to be separated; however, axons from the ispalateral eye continue to cover a larger area of the dLGN and multiple ipsalateral termination zones are seen rather than a single zone as in wild-type

• however, targeting of retinal ganglion cell axons through the optic chiasm is similar to wild-type

vision/eye

abnormal eye electrophysiology ( J:109215 )

• retinal ganglion cells display increased average action potential burst duration mostly due to the absence of burst shorter than 1.5 sec in duration

• retinal ganglion cells have a significantly higher overall spike rate and a slightly higher instantaneous firing frequency; however the correlation between near and distant spikes is maintained

• retinal ganglion cells cultured for 2 weeks with wild-type glia show delayed development of glutamatergic synaptic function

• however, visual transmission and visually mediated behavior in adult mice is similar to wild-type and no defects in hippocampal function are detected at P20 - P40

behavior/neurological

behavior/neurological phenotype ( J:109215 )

N • visually mediated behavior in adult mice is similar to wild-type