Phenotypes Associated with This Genotype

Genotype
MGI:3625035

• Allelic Composition: Pmp22^tm1Lnot/Pmp22⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal myelin sheath morphology ( J:104989 )

• tomacula, sausage-like myelin thickenings, are seen on the sciatic nerve; however these are less common than in homozygotes

• the frequency of tomacula increases with age

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:104989 )

• motor deficits are seen by 5 months of age, later than in homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary neuropathy with liability to pressure palsies		DOID:0060843	OMIM:162500	J:104989