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Phenotypes Associated with This Genotype
Genotype
MGI:3624833
hm1
Allelic
Composition
Nogtm1Amc/Nogtm1Amc
Genetic
Background
B6.129S1-Nogtm1Amc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nogtm1Amc mutation (3 available); any Nog mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: embryo death before E14.5 on a B6.129S1 background

embryo
• Background Sensitivity: reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background

hearing/vestibular/ear
• at E17.5 incus is malformed
• at E17.5 malleus is malformed
• at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities

craniofacial
• at E17.5 incus is malformed
• at E17.5 malleus is malformed
• at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities

limbs/digits/tail
• Background Sensitivity: reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background

skeleton
• at E17.5 incus is malformed
• at E17.5 malleus is malformed
• at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory