Phenotypes Associated with This Genotype

Genotype
MGI:3624833

hm1

• Allelic Composition: Nog^tm1Amc/Nog^tm1Amc
• Genetic Background: B6.129S1-Nog^tm1Amc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:108573 )

• Background Sensitivity: embryo death before E14.5 on a B6.129S1 background

embryo

small limb buds ( J:108573 )

• Background Sensitivity: reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background

hearing/vestibular/ear

abnormal incus morphology ( J:132023 )

• at E17.5 incus is malformed

abnormal malleus morphology ( J:132023 )

• at E17.5 malleus is malformed

fusion of middle ear ossicles ( J:132023 )

• at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities

craniofacial

abnormal incus morphology ( J:132023 )

• at E17.5 incus is malformed

abnormal malleus morphology ( J:132023 )

• at E17.5 malleus is malformed

fusion of middle ear ossicles ( J:132023 )

• at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities

limbs/digits/tail

small limb buds ( J:108573 )

• Background Sensitivity: reduction in limb buds is seen on the C57BL/6 background but not so much on a CD-1 background

skeleton

abnormal incus morphology ( J:132023 )

• at E17.5 incus is malformed

abnormal malleus morphology ( J:132023 )

• at E17.5 malleus is malformed

fusion of middle ear ossicles ( J:132023 )

• at E17.5 embryos display overgrown and fused ossicles not identifiable as discrete entities