Phenotypes for Tor1a MGI:3624527 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tor1a^tm2Wtd/Tor1a⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tor1a^tm2Wtd mutation (1 available); any Tor1a mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:107596 )

• nuclear envelope is normal compared to homozygous Tor1a homozygous or compound mutants

nervous system

abnormal neuron physiology ( J:201535 )

• hippocampal neurons exhibit a prolonged cytoplasmic calcium concentration decay, indicating that neurons experience calcium overload

• treatment with glutamate-receptor antagonist results in the ablation of this prolonged decay

behavior/neurological

behavior/neurological phenotype ( J:185289 )

N	• males have no apparent behavioral abnormalities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
torsion dystonia 1		DOID:0060730	OMIM:128100	J:201535

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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