Phenotypes Associated with This Genotype

Genotype
MGI:3623741

hm2

• Allelic Composition: Utrn^tm1Jrs/Utrn^tm1Jrs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:89397 )

• homozygotes are more sensitive to the excitoxic effects of kainate injections, with a higher mortality and more extensive development of hippocampal sclerosis, however susceptibility to kainate induced seizures is similar to that of wild-type

nervous system

abnormal nervous system physiology ( J:89397 )

• homozygotes are more sensitive to the excitoxic effects of kainate injections, with a higher mortality and more extensive development of hippocampal sclerosis, however susceptibility to kainate induced seizures is similar to that of wild-type

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:89397 )

• homozygotes are more sensitive to the excitoxic effects of kainate injections, with a higher mortality and more extensive development of hippocampal sclerosis, however susceptibility to kainate induced seizures is similar to that of wild-type