Phenotypes Associated with This Genotype

Genotype
MGI:3623576

• Allelic Composition: Casp3^tm1Mak/Casp3^tm1Mak
• Genetic Background: B6.129P2-Casp3^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:97650 )

• about 50% of homozygotes survive to adulthood

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:97650 )

• after injection with streptozocin for 5 consecutive days, blood glucose in homozygotes remains normoglycemic for the duration of the study and pancreas samples showed normal islets

immune system

decreased inflammatory response ( J:97650 , J:179279 )

• islets from homozygous mice show no infiltration at any time after streptozocin treatment compared to heterozygotes (J:97650)

• after treatment with TNF unlike in wild-type mice swollen villi, an increase in infiltrates, and high levels of apoptosis are almost absent (J:179279)

• however, cytokine concentrations, hypothermia, and mortality after TNF treatment are similar to wild-type controls (J:179279)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:97650