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Phenotypes Associated with This Genotype
Genotype
MGI:3622763
Allelic
Composition		 Prf1tm1Clrk/Prf1tm1Clrk
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Clrk mutation (2 available); any Prf1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:64051 )
• mice do not develop diabetes over 12 weeks while transgenic littermates all develop diabetes (blood glucose >300mg/dl) in the same period

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:64051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory