Analysis Tools
immune system
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• in culture, LPS-stimulated spleen cells from null mice produce greater levels of TNF than wild-type control cells
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• on day 53, the joints of null animals have a pannus score 2.4 fold higher compared to wild-type
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• on day 53, the joints of null animals have a 2.2 fold greater mean inflammation score than wild-type, with a pannus score 2.4 fold higher, the cartilage damage score 2.3 fold greater and the bone damage score 2.3 fold greater
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• after immunization with collagen II on day 21, clinical disease activity score is higher in knockouts by between days 36 and 53 after the initial injection compared with wild-type
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skeleton
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• on day 53, the joints of null animals have a pannus score 2.4 fold higher compared to wild-type
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• on day 53, the joints of null animals have a 2.2 fold greater mean inflammation score than wild-type, with a pannus score 2.4 fold higher, the cartilage damage score 2.3 fold greater and the bone damage score 2.3 fold greater
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• after immunization with collagen II on day 21, clinical disease activity score is higher in knockouts by between days 36 and 53 after the initial injection compared with wild-type
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