Phenotypes Associated with This Genotype

Genotype
MGI:3619459

• Allelic Composition: Tg(IGL-MYC)3Hm/0
• Genetic Background: C57BL/6N-Tg(IGL-MYC)3Hm/Nci

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:65245 )

• most mice hemizygous for the transgene die between the ages of 2 and 6 months

immune system

enlarged lymph nodes ( J:65245 )

• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly

neoplasm

increased B cell derived lymphoma incidence ( J:65245 )

• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM⁺CD19⁺CD5^-CD23^- cells"

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:65245