Phenotypes Associated with This Genotype

Genotype
MGI:3618387

• Allelic Composition: Mbl1^tm1Kata/Mbl1^tm1Kata; Mbl2^tm1Kata/Mbl2^tm1Kata
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal complement pathway ( J:106351 )

• after 45 min ischemia followed by 2 h reperfusion, complement activation as assessed by plasma C3a (desArg) level is significantly greater in wild-type mice than in double homozygous mutants; by 24 h, both groups have C3a levels < 30 ng/ml

abnormal response to infection ( J:106352 )

• doubly homozygous mutant mice infected intraperitoneally with herpes simplex virus type II (HSV-2) begin to clear the infection more slowly from the liver than do wild-type mice; however, complete clearance occurs in both by 6 days post-infection

• the proportion of HSV-2 neutralized in vitro after 9 minutes' exposure to serum from double homozygotes is significantly lower than after incubation with serum from wild-type mice; however, both have neutralized 90% of virus after > 21 minutes

increased susceptibility to bacterial infection ( J:106353 )

• all doubly homozygous mutant mice, but only 30% of wild-type mice, die within 42 h after burning of 5% of total body surface area (TBSA) followed by subcutaneous (s.c.) inoculation with Pseudomonas aeruginosa, whereas neither mutant nor wild-type mice appear ill following either treatment alone

• P. aeruginosa titers in plasma and homogenates of blood, liver and kidney harvested 20 h after the postburn inoculation are significantly higher in double homozygous than in wild-type mice; however, titers in lung and in skin do not differ significantly

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:106351 )

• doubly homozygous mutant mice exhibit significantly less elevation of blood urea nitrogen (BUN) levels than do wild-type mice following induction of bilateral kidney eschemia (45 min) and reperfusion (24 h)

• after 45 min ischemia followed by 2 or 24 h reperfusion, histological examination of wild-type kidneys reveals severe tubular damage characterized by dilation, necrosis and presence of proteinaceous casts; kidneys of double homozygous mice exhibit no such damage

homeostasis/metabolism

decreased susceptibility to kidney reperfusion injury ( J:106351 )

• doubly homozygous mutant mice exhibit significantly less elevation of blood urea nitrogen (BUN) levels than do wild-type mice following induction of bilateral kidney eschemia (45 min) and reperfusion (24 h)

• after 45 min ischemia followed by 2 or 24 h reperfusion, histological examination of wild-type kidneys reveals severe tubular damage characterized by dilation, necrosis and presence of proteinaceous casts; kidneys of double homozygous mice exhibit no such damage