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Phenotypes Associated with This Genotype
Genotype
MGI:3603406
Allelic
Composition
Tg(Ins2-TCF1*P291)2Kya/0
Genetic
Background
involves: C57BL/6 * SJL
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased glucose-stimulated insulin secretion
• nonfasting blood glucose levels at 4 weeks are higher, especially in males

endocrine/exocrine glands
• islets are smaller in size, contain fewer insulin-positive cells, and are irregularly shaped
• decreased by 50% and 58% at 2 and 4 weeks of age, respectively
• beta-cells intermingle with non-beta-cells within the islet core and compacted beta-cell-to-beta-cell contact is abolished
• reduced changes in intracellular calcium in islets in response to glucose
• reduced pancreatic insulin content
• reduced beta-cell proliferation in islets
• reduced beta-cell proliferation in islets
• decreased glucose-stimulated insulin secretion

cellular
• reduced beta-cell proliferation in islets

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 3 DOID:0111102 OMIM:600496
J:73760


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory