Phenotypes Associated with This Genotype

Genotype
MGI:3589901

• Allelic Composition: Klb^tm1Yin/Klb^tm1Yin
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

small gallbladder ( J:100209 )

• on an atherogenic diet the gall bladder in homozygotes is smaller

abnormal liver physiology ( J:100209 )

• bile acid synthesis is increased

homeostasis/metabolism

abnormal bile salt homeostasis ( J:100209 )

• fecal bile acid excretion is dramatically elevated and the bile acid pool size is slightly increased (only significant in males)

• on an atherogenic diet homozygotes are resistant to gallstone formation

growth/size/body

decreased body weight ( J:100209 )

• slight but significant decrease in body weight

endocrine/exocrine glands

small gallbladder ( J:100209 )

• on an atherogenic diet the gall bladder in homozygotes is smaller