Phenotypes for Chek1 Trp53 MGI:3588912 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Chek1^tm1Sje/Chek1^tm1Sje Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm1Sje mutation (0 available); any Chek1 mutation (41 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:62919 )

• die by E2.5-3.5

• the presence of the p53 mutant allele does not rescue or delay the lethality phenotype of the single Chek1^tm1Sje mutation

cellular

increased apoptosis ( J:62919 )

• TUNEL-positive cells are observed in double mutant blastocysts to a similar degree as the singly Chek1^tm1Sje mutant blastocysts, but not in control blastocysts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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