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Phenotypes Associated with This Genotype
Genotype
MGI:3583156
Allelic
Composition
Cd14tm1Frm/Cd14tm1Frm
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14tm1Frm mutation (2 available); any Cd14 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages exhibited loss of cytokine production in response to LPS and low levels of heat-killed E.coli (less than 1 E.coli per cell), however macrophages stimulated with high levels (10 E.coli per cell) of heat-killed E.coli, produced cytokine levels similar to wild-type while macrophages stimulated with lower levels (less than 10 E.coli per cell) produced reduced cytokine levels
• no IL-6 production by macrophages in response to LPS from E.coli K235
• no TNF-alpha production by macrophages in response to LPS from E.coli K235 or to low levels of heat-killed E.coli (less than 1 E.coli per cell)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory