Phenotypes Associated with This Genotype

Genotype
MGI:3582952

• Allelic Composition: Bicc1^jcpk/Bicc1^jcpk
• Genetic Background: involves: 101 * C3H * T STOCK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:23047 , J:27506 )

• generally die between 7 to 10 days after birth with none surviving longer than 20 days (J:27506)

renal/urinary system

kidney cyst ( J:23047 , J:27506 )

• cysts are evident at birth and increase in number and size with age (J:23047)

• cysts are initially found in the inner cortical and medullary regions, by 4 days of age cysts have expanded to involve most areas of the kidney including the outer cortex, and by 7 days virtually the entire kidney is affected (J:23047)

liver/biliary system

dilated bile duct ( J:23047 )

enlarged gallbladder ( J:23047 )

• about 50% of homozygotes have an enlarged gallbladder

digestive/alimentary system

dilated pancreatic duct ( J:23047 )

• dilation of the pancreatic duct

growth/size/body

enlarged gallbladder ( J:23047 )

• about 50% of homozygotes have an enlarged gallbladder

kidney cyst ( J:23047 , J:27506 )

• cysts are evident at birth and increase in number and size with age (J:23047)

• cysts are initially found in the inner cortical and medullary regions, by 4 days of age cysts have expanded to involve most areas of the kidney including the outer cortex, and by 7 days virtually the entire kidney is affected (J:23047)

decreased body size ( J:27506 )

distended abdomen ( J:23047 )

• seen at 3 to 10 days of age

endocrine/exocrine glands

dilated pancreatic duct ( J:23047 )

• dilation of the pancreatic duct

dilated bile duct ( J:23047 )

enlarged gallbladder ( J:23047 )

• about 50% of homozygotes have an enlarged gallbladder

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:23047