Phenotypes Associated with This Genotype

Genotype
MGI:3582871

hm2

• Allelic Composition: Krt8^tm1Rgo/Krt8^tm1Rgo
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased polyploid hepatocyte number ( J:106541 )

• liver lesions, necrosis and abnormal hepatocyte cell cycle correlating with multinuclear cells and abnormal hepatocellular architecture

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:22116 )

• Background Sensitivity: 36% of homozygotes survive to adulthood after one backcross to FVB/N

• Background Sensitivity: 55% of homozygotes survive to adulthood after two or more backcrosses to FVB/N

digestive/alimentary system

diarrhea ( J:89299 )

• watery stools

abnormal intestinal epithelium morphology ( J:118021 )

• mistargeting of apical membrane proteins in the epithelium of the small intestine

abnormal colon morphology ( J:89299 , J:22116 )

• frequent mitotic colonocytes (J:89299)

• colonocyte sloughing into the lumen in some areas (J:89299)

• hyperplastic lesions in the colon and rectum (J:22116)

• elongated villi (J:22116)

rectal prolapse ( J:22116 )

• anorectal prolapse developing between 9 weeks and 1 year of age

abnormal intestinal mineral absorption ( J:89299 )

• decreased net sodium absorption

• significantly decreased net chloride flux resulting in net chloride secretion

hematopoietic system

enlarged spleen ( J:22116 )

• moderate splenomegaly

liver/biliary system

liver hemorrhage ( J:86719 )

• increased hemorrhage seen in the liver on a lithogenic diet

abnormal hepatocyte morphology ( J:44938 , J:86719 , J:106541 , J:121813 )

• reduced viability of hepatocytes isolated by collagenase perfusion compared to wild-type (J:44938)

• nucleus of hepatocytes often displaced to the periphery of the cell when on a lithogenic diet (J:86719)

• liver lesions, necrosis and abnormal hepatocyte cell cycle correlating with multinuclear cells and abnormal hepatocellular architecture (J:106541)

• increased sensitivity of hepatocytes to apoptosis (J:121814) (J:121813)

increased polyploid hepatocyte number ( J:106541 )

• liver lesions, necrosis and abnormal hepatocyte cell cycle correlating with multinuclear cells and abnormal hepatocellular architecture

hepatic necrosis ( J:86719 , J:22116 )

hepatic steatosis ( J:86719 )

• liver steatosis develops on a lithogenic diet

cardiovascular system

liver hemorrhage ( J:86719 )

• increased hemorrhage seen in the liver on a lithogenic diet

immune system

enlarged spleen ( J:22116 )

• moderate splenomegaly

chronic inflammation ( J:86719 , J:98058 )

• increased inflammation on a lithogenic diet (J:86719)

• Th-2 mediated inflammation of the colon (J:98058)

reproductive system

female infertility ( J:22116 )

♀ • Background Sensitivity: females are sterile but males are normally fertile

growth/size/body

decreased body weight ( J:89299 )

enlarged spleen ( J:22116 )

• moderate splenomegaly