Phenotypes Associated with This Genotype

Genotype
MGI:3581823

• Allelic Composition: Tg(GFAP)7Mes/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte morphology ( J:99256 )

• astrocytes are enlarged and contain large eosinophilic aggregations resembling Rosenthal fibers; however unlike mice from high expressing lines mice from low expressing lines have normal life spans

cellular

abnormal astrocyte morphology ( J:99256 )

• astrocytes are enlarged and contain large eosinophilic aggregations resembling Rosenthal fibers; however unlike mice from high expressing lines mice from low expressing lines have normal life spans

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alexander disease		DOID:4252	OMIM:203450	J:99256