Phenotypes Associated with This Genotype

Genotype
MGI:3581521

• Allelic Composition: Casp1^tm1Sesh/Casp1^tm1Sesh; Casp4^del/Casp4^del
• Genetic Background: NOD.129S2(B6)-Casp1^tm1Sesh Casp4^del/LtJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-1 alpha secretion ( J:87250 )

• cultured LPS-stimulated bone marrow derived macrophages from homozygous mutants secrete 20%-30% less IL-1alpha relative to heterozygous or wild-type (NOD/Lt) mice

decreased interleukin-1 beta secretion ( J:87250 )

• cultured LPS-stimulated bone marrow derived macrophages from homozygous mutants secrete 4-fold less IL-1beta relative to heterozygous or wild-type (NOD/Lt) mice

decreased interleukin-18 secretion ( J:87250 )

• cultured LPS-stimulated bone marrow derived macrophages from homozygotes produce no immunoreactive IL18 relative to heterozygous or wild-type (NOD/Lt) mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:87250 )

N • homozygotes show no significant differences in the rate or in total incidence of diabetes relative to heterozygotes or wild-type (NOD/Lt) control mice

N • weanling homozygotes injected with Complete Freund's adjuvant and young pre-diabetic males treated with multiple low dose streptozotocin behave similarly to control (wild-type, heterozygous, or NOD/Lt) mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:87250