Phenotypes Associated with This Genotype

Genotype
MGI:3580009

• Allelic Composition: Map4k4^tm1Eys/Map4k4^tm1Eys
• Genetic Background: either: (involves: 129S/SvEv * Swiss Webster) or (involves: CD-1 * Swiss Webster)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:68215 )

• no homozygotes born

• at E9.0 embryos have a beating heart

• homozygous embryos at E10.5 are small, necrotic and partially resorbed

embryo

sirenomelia ( J:68215 )

• failure of the embryo to elongate posteriorly

• truncated body, relatively normal anterior fold-like structures and relatively normal allantois

• posterior thickening of the embryo at E7-E7.5

embryonic growth retardation ( J:68215 )

abnormal primitive streak morphology ( J:68215 )

• thickened anterior and mid sections of the primitive streak

• failure of committed mesoderm cells to migrate away from the primitive streak

abnormal anterior primitive streak morphology ( J:68215 )

• thickened

absent somites ( J:68215 )

• usually lacking somites

• occasionally 1-2 anterior somites, never any posterior

growth/size/body

embryonic growth retardation ( J:68215 )

limbs/digits/tail

sirenomelia ( J:68215 )

• failure of the embryo to elongate posteriorly

• truncated body, relatively normal anterior fold-like structures and relatively normal allantois

• posterior thickening of the embryo at E7-E7.5