Phenotypes for Ccl3 Hexb MGI:3579805 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ccl3^tm1Unc/Ccl3⁺ Hexb^tm1Rlp/Hexb^tm1Rlp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (2 available); any Ccl3 mutation (21 available)
Hexb^tm1Rlp mutation (1 available); any Hexb mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:90687 )

• life span of approximately 138 day

behavior/neurological

abnormal motor coordination/balance ( J:90687 )

• improved performance on a rotarod compared to mice homozygous for the Hexb allele alone

abnormal righting response ( J:90687 )

• improved relative to mice homozygous for the Hexb allele alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sandhoff disease		DOID:3323	OMIM:268800	J:90687

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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