Phenotypes Associated with This Genotype

Genotype
MGI:3579102

cx2

• Allelic Composition: H1f6^tm1Drab/H1f6^tm1Drab; Smcp^tm1Wen/Smcp^tm1Wen; Tnp2^tm1Wen/Tnp2^tm1Wen
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

asthenozoospermia ( J:98301 )

♂ • significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract

♂ • smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice

reproductive system

asthenozoospermia ( J:98301 )

♂ • significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract

♂ • smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice

male infertility ( J:98301 )

♂ • produced no offspring when mated to wild-type females

impaired fertilization ( J:98301 )

• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)

impaired sperm penetration of zona pellucida ( J:98301 )

♂ • impaired sperm penetration of zona pellucida from wild-type females