Phenotypes for Acr H1f6 Smcp MGI:3579101 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Acr^tm1Wen/Acr^tm1Wen H1f6^tm1Drab/H1f6^tm1Drab Smcp^tm1Wen/Smcp^tm1Wen
Genetic Background	involves: 129/Sv * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acr^tm1Wen mutation (0 available); any Acr mutation (50 available)
H1f6^tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcp^tm1Wen mutation (0 available); any Smcp mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm head morphology ( J:98301 )

• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type

impaired sperm migration in female genital tract ( J:98301 )

• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired

asthenozoospermia ( J:98301 )

• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type

• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice

reduced male fertility ( J:98301 )

• litter size was sharply reduced when mutant males were mated to wild-type females

impaired fertilization ( J:98301 )

• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)

impaired binding of sperm to zona pellucida ( J:98301 )

• reduced binding of sperm to zona pellucida from wild-type females

cellular

abnormal sperm head morphology ( J:98301 )

• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type

impaired sperm migration in female genital tract ( J:98301 )

• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired

asthenozoospermia ( J:98301 )

• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type

• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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