Analysis Tools
reproductive system
immune system
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• apoptotic cell phagocytosis by macrophages is reduced
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• the spleen is enlarged and apoptotic cells accumulate in the spleen
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cardiovascular system
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• in a surgically induced ischemic hindlimb model VEGFA treatment does not stimulate neovessel formation in mutants unlike in wild-type mice; however FGF2 treatment stimulates neovessel formation in both mutant and wild-type mice
• neovascularization of implanted matrigel is reduced in VEGFA-treated homozygotes compared to wild-type mice; however, embryonic vascular development is normal
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renal/urinary system
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• in aging homozygotes, immunoglobulin deposits are seen in the kidney
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hematopoietic system
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• apoptotic cell phagocytosis by macrophages is reduced
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• the spleen is enlarged and apoptotic cells accumulate in the spleen
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growth/size/body
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• the spleen is enlarged and apoptotic cells accumulate in the spleen
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cellular
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• apoptotic cell phagocytosis by macrophages is reduced
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