Analysis Tools
mortality/aging
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• 1 mouse survived past 3 months
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• very few survive to E15.5-E18.5 (2 in 60 embryos)
• relatively few born (4.5%)
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• 6 of 13 mice born alive died within a few days of birth
• 6 of 13 mice born alive died around weaning
• 1 survived past 3 months
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• at E7.5, 16.5% of embryo were live homozygotes, an additional 7.4% of embryos were dead homozygotes
• implantation was normal with death occurring during gastrulation and organogenesis
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growth/size/body
malocclusion
(
J:98073
)
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• sometimes upper and lower incisors are misaligned
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• sometimes curved to right or left
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• lateral bending of snout with and without misalignment of incisors
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short snout
(
J:98073
)
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• grossly normal at birth but severely growth retarded thereafter
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craniofacial
malocclusion
(
J:98073
)
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• sometimes upper and lower incisors are misaligned
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• sometimes curved to right or left
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• lateral bending of snout with and without misalignment of incisors
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short snout
(
J:98073
)
skeleton
polyphalangy
(
J:98073
)
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• extra cartilage seen in digit 5
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malocclusion
(
J:98073
)
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• sometimes upper and lower incisors are misaligned
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• sometimes curved to right or left
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• hypoplastic thyroid bones with central elements unformed
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• 13th rib is thinner than normal and fails to articulate with vertebral body
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• dorsal arches of some thoracic vertebrae failed to close
• T2 lacked spinal processes
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• restricted head rotation
• failure of some dorsal arches to close
• C4, C5, C6 transverse foramina failed to close
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• odontoid process fused to atlas
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• failure of some cervical and thoracic dorsal arches to close
• C4, C5, C6 transverse foramina failed to close
• dorsal arches of some thoracic vertebrae failed to close
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limbs/digits/tail
polyphalangy
(
J:98073
)
|
• extra cartilage seen in digit 5
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respiratory system
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• sometimes curved to right or left
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• hypoplastic thyroid bones with central elements unformed
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behavior/neurological
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• mice display defective context-dependent learning relative to wild-type mice
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• mice display defective cued (tone) conditioned learning relative to wild-type mice
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• in a light-dark test, mice display increased latency to enter the light relative to wild-type mice
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• when suspended by their tails, mice display hindlimb, and occasionally hind- and forelimb, clasping even after three months of age whereas wild-type mice hold their legs apart
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• when placed on a vertical pole, mice fall off more frequently and more readily as compared to wild-type mice
• in a wire suspension test, mice fall off after 30 seconds compared to 60 seconds for heterozygotes
• when placed on a thin rod, mice fall off after 11 seconds compared to 60 seconds for wild-type mice
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• seizures are observed after 3 months of age
• sudden behavioral arrest correlates with electrographic seizures
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nervous system
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• seizures are observed after 3 months of age
• sudden behavioral arrest correlates with electrographic seizures
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• video electroencephalogram indicates abnormal wake and sleep background punctuated by generalized spikes, multiple spikes and sharp waves
• sudden behavioral arrest correlates with electrographic seizures
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