Phenotypes Associated with This Genotype

Genotype
MGI:3575128

• Allelic Composition: Il7^hlb368/Il7^hlb368
• Genetic Background: C57BL/6J-Il7^hlb368/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:118450 )

• normal medullary and corical zone morphology despite reduced size

thymus hypoplasia ( J:118450 )

• cell number in the thymus is reduced to 10% of normal mice

abnormal T cell subpopulation ratio ( J:118450 )

• in the thymus, the ratios of CD4 to CD8 cells were slightly increased with the absolute percentages of these cells similar to controls

• in the spleen, the ratios are normal, despite an overall absolute reduction of T cells by 80%

decreased leukocyte cell number ( J:82961 , J:118450 )

• CBC of 1.50 x 10³ WBC/l at 8 weeks of age (J:82961)

• retesting at 10 weeks of age confirmed leukopenia, with 2.51 x 10³ WBC/l (J:82961)

• nonfasted WBC is 1.5 x 10³ WBC/l (J:118450)

decreased T cell number ( J:118450 )

• 80% reduction in the absolute number of T cells in the spleen, suggesting defects in T cell proliferation and expansion

small spleen ( J:118450 )

• grossly normal architecture despite small size

spleen hypoplasia ( J:118450 )

• cell number in the spleen is reduced to 40% of normal mice

absent Peyer's patches ( J:118450 )

absent mesenteric lymph nodes ( J:118450 )

absent axillary lymph nodes ( J:118450 )

absent cervical lymph nodes ( J:118450 )

small inguinal lymph nodes ( J:118450 )

• detectable, but markedly reduced in size

absent popliteal lymph nodes ( J:118450 )

hematopoietic system

small thymus ( J:118450 )

• normal medullary and corical zone morphology despite reduced size

thymus hypoplasia ( J:118450 )

• cell number in the thymus is reduced to 10% of normal mice

abnormal T cell subpopulation ratio ( J:118450 )

• in the thymus, the ratios of CD4 to CD8 cells were slightly increased with the absolute percentages of these cells similar to controls

• in the spleen, the ratios are normal, despite an overall absolute reduction of T cells by 80%

decreased leukocyte cell number ( J:82961 , J:118450 )

• CBC of 1.50 x 10³ WBC/l at 8 weeks of age (J:82961)

• retesting at 10 weeks of age confirmed leukopenia, with 2.51 x 10³ WBC/l (J:82961)

• nonfasted WBC is 1.5 x 10³ WBC/l (J:118450)

decreased T cell number ( J:118450 )

• 80% reduction in the absolute number of T cells in the spleen, suggesting defects in T cell proliferation and expansion

small spleen ( J:118450 )

• grossly normal architecture despite small size

spleen hypoplasia ( J:118450 )

• cell number in the spleen is reduced to 40% of normal mice

endocrine/exocrine glands

small thymus ( J:118450 )

• normal medullary and corical zone morphology despite reduced size

thymus hypoplasia ( J:118450 )

• cell number in the thymus is reduced to 10% of normal mice