Phenotypes Associated with This Genotype

Genotype
MGI:3574750

• Allelic Composition: Adamts1^tm1Mapr/Adamts1^tm1Mapr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:96781 )

• the expected Mendelian ratio of null mice was present on the day preceding birth but only 55% remained on the day after birth

postnatal lethality, incomplete penetrance ( J:96781 )

• of those surviving after day 1, most survived to adulthood with 40% surviving at time of weaning

renal/urinary system

abnormal kidney morphology ( J:96781 )

• on the day following birth, pups showed a shrinkage of both layers of the kidney and an enlarged caliceal space, however kidneys were normal at E18.5

kidney cortex atrophy ( J:96781 )

• a reduction of cortical width is seen on the day after birth

kidney medulla atrophy ( J:96781 )

• a reduction of medullary width is seen on the day after birth

dilated kidney calyx ( J:96781 )

• on the day following birth, pups displayed an enlarged caliceal space

reproductive system

decreased ovulation rate ( J:96781 )

♀ • release of oocytes from the follicles was reduced by 70% resulting in a decreased number of oocytes in the oviducts and the number of implantation sites was reduced by 43%, however females have a normal uterus and estrous cycle

♀ • several oocytes were found to be trapped in the corpora lutea after ovulation

reduced female fertility ( J:96781 )

♀ • 38% of females give birth to pups after plug formation

♀ • the pregnancy rate was decreased during gestation at a greater rate (83% at E4.5 to 50% at E15.5) compared with wildtype (100% at E4.5 to 83% at E15.5), suggesting a loss of embryos as pregnancy progressed

decreased litter size ( J:96781 )