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Phenotypes Associated with This Genotype
Genotype
MGI:3510920
Allelic
Composition		 Tg(ALB-cre,CMV-rtTA)#Wcyy/0
Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy/0
Genetic
Background		 involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:93624 )
• serum cholesterol is reduced 35-40% 5 days after doxycycline treatment compared to untreated controls

liver/biliary system
hepatic steatosis ( J:93624 )
• lipid accumulation is seen only in the liver after doxycycline treatment

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Tangier disease DOID:1388 OMIM:205400
 J:93624

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory